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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

整个夏天,每隔一周,Good Humor冰淇淋卡车在周五午餐时就会拜访这家公司。而在秋季,公司每个月有两个上午会给大家提供苹果酒和甜甜圈。
5. Repeats & highlights are as good as the main match, so am gonna watch them.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: 家居销售下半年市场比上半年艰难
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

作为每年都会有超过100万人参加的国家级考试,研究生入学考试对于学生的学习生涯是非常重要的,而作弊事件也一而再再而三被曝光。
"Well, I am going to have a Cabinet that looks like America," the former secretary of state replied. "And 50 percent of America is women, right?"

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
From the themed collection: 近九成受访者被居家安全问题困扰
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

SplashData公司首席执行官摩根-斯莱恩说:“不幸的是,虽然最新的一部星球大战系列电影很精彩,但使用‘starwars’这个密码却很危险。”

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 房企分拆物业上市热潮卷土重来?
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

谎言10:我以为我早就把邮件发出去了。我真的发过了。说谎原因:如果告诉你我觉得这事不重要,我把这事忘了,就会伤害到我俩的关系了。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

我们首先得明白我们所有人都不知道这次选秀会怎么发展,毕竟大学联赛还在进行。但当所有的这些新鲜的血液都齐聚乐透区,这看起来当然美如画。
债券大王比尔?格罗斯(Bill Gross)承认:“QE必须结束。”数万亿的低成本资金“扭曲了激励机制,将资产价格推高至人为水平”。但现在格罗斯说“美联储的计划可能过于仓促了”。
'How do I explain the fact that I got a GQ Man of the Year award and no women's magazines and no women's organisations have supported me?
Adding to the growing literature of sell-side analysts who think the answer to Apple's (AAPL) market valuation woes (down 35% since September) is a low-cost iPhone, MorganStanley's Katy Huberty has looked at China, the world's largest smartphone market, and done the math.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

4. 贵金属:“都在玩消失!经济周期下行”
Her subjects felt like they were waiting in a long line to reach the top of a hill where the American dream was waiting for them. But the line’s uphill progress had slowed, even stopped. And immigrants, black people and other “outsiders” seemed to be cutting the line.
中国与世界其他地区的贸易10月同比大幅下滑,原材料进口受到尤其沉重的打击,中国投资放缓削弱了这个全球最大商品贸易国的需求。
我经常心情不好

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

East Asia's cinephiles won't have a local favorite to cheer during this year's foreign-language Academy Awards race after the Taiwan epic 'Warr

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

Statistics show global research and development expenditure grew at an annual pace of approximately seven percent before 2009, but slowed down to four percent in 2014

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: “以房养老”保险3年只卖了90份
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

不过现在,她已经开始利用自己童话公主一般的面容做慈善事业了,她会装扮成童话角色的样子,为孩子们演出,为癌症患儿的家长加油鼓劲。
通用汽车现在已经对挥泪大促销上瘾,新首席执行长惠塔克里(Ed Whitacre)对此心知肚明。他将在2010年取消一些购买刺激措施,以放弃全美20%市场占有率目标的方式来谋求重获盈利能力。这番求索注定是前路艰难。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

室内环境:这栋房屋在1848年前后建成,上次翻修是在2008年。房屋前门上方有一扇气窗,侧灯的红色玻璃上蚀刻有叶形花纹。屋内一楼有一间带有顶冠装饰板条和两座壁炉的大客厅,其中的一座壁炉给这间正式的餐厅区供暖。客厅外是一间家庭娱乐室,内有凸起的护壁板、一个带有水槽的吧台和另一处餐厅区。那扇法式双开门通往一处铺着石板的露台。有些房间可观赏小纳拉甘西特湾的景观。
The fundamentals of the Chinese economy remain sound, the capital adequacy ratio and provision coverage of commercial bans remain high, and we have many financial tools and instruments that can be used. We have the confidence, the ability, and the means to forestall systemic risks.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Juckes warns that we're now trapped in the fourth megabubble fueled by the Federal Reserve in the last 30 years, since the rise of conservative economics. He calls this one, the Bubble With No Name Yet. OK, we invite you to send in your nomination to name the new bubble. But whatever you call it, do it fast, it's close to popping, like the Asian, Dot-com and Credit crashes the last 30 years.
rough

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 盈利未达预期 龙湖冠寓换帅求变
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

And others simply disappeared:
“The key thing about Friends is that it’s about people working out how they are going to live their lives — what kind of relationships are they going to have, what kind of job, and the difficulties of settling down,” says Mills to the Daily Mail. “You’re engaged in all those questions about escaping from your family, becoming an adult and working out what you want to be.”And that’s one of the key issues in the youth culture of the 1990s.
该项调研还显示,会计与金融专业的毕业生也将走俏。那些已在为明年夏天毕业后的生路做打算的学生们需要谨记:上述调研中,有52%的受访雇主表示,他们更愿意雇佣有实习经验的毕业生。
8.The Big Bang Theory Whiteboard Has Real Equations

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

日本央行行长黑田东彦(Haruhiko Kuroda)表示:“我觉得我们可以对全球前景持谨慎乐观态度。”

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
From the themed collection: 处理废弃家具将收费?
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

syn=same,drome一次流出-一次流出相同症状-综合症状syn=same;drome=drone(n 雄蜂;v 嗡嗡作声)-同样的症状嗡嗡的过来-综合症状
Against: There was no love from the New York nor LA critics.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

考辛斯的交易有资格作为一枚重磅炸弹,猛龙用两笔大交易确立了他们东部冠军挑战者的位置,以及,在另外的故事情节中,西部最后一个季后赛席位的争夺将愈演愈烈。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

Norway, which has twice rejected European Union membership, ranks No. 10 overall. The country takes the No. 1 spot in Citizenship and the No. 2 spot in Most Transparent.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

新年是这样美好的时光:炉火熊熊,花儿芬芳,醇酒飘香,殷殷祝福,美好回忆,
圣文森特(St. Vincent),《数码证人》(Digital Witness), Loma Vista/Republic
The Sports Illustrated Swimsuit Issue model Kate Upton stands 8th on the world's most beautiful women of 2015 list. This modern fashion model was at No. 2 in last year list. She also was named the sexiest women by People magazine.
boring

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

该项目的另一个好处在于,它鼓励了职业灵活性,让年轻人对曲折的职业道路有所准备,而后者可能在现代职场中是必不可少的。
他做出了不从事企业战略工作的战略性转变,尽管他自己的学校曾经建议他别从事教育方面的职业,虽然他担任过私人教师。
近几个月,为了遏制资本外流、缓解人民币贬值压力,中国监管机构针对海外并购出台了一系列新限制措施。2016年,中国企业对外非金融类直接投资额激增44%,达到创纪录的1700亿美元。
Sonneborn, who lives in Bristol, Vermont, with his parents and younger sister, Julia, 11, is seeking the Democratic nomination.
在那之前,她曾出演过大受欢迎的情景剧,并且也因饰演的角色而小有名气。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

The Lost Tomb
2. The new one childplus policy will substantially raise the birth rate, contributing up to 2million new children to the 2014 economy, a 15 percent one-year lift that willonly further boost consumer morale and spirit.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

A robust LinkedIn presence is crucial to any job search. You know that. Your manager knows that. And your manager probably knows that you know that – so she'll be concerned when you go from having a bare-bones profile on Monday to one jacked with additional work history, new connections, status updates and recommendations by Friday. "Don't go from zero to 500 overnight, because that can be quite obvious," Foss cautions。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

在一份电邮声明中,国际足联表示,在小组赛中,三等票总计售出143364张,相当于每场比赛就卖出了3000张。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Profits at China’s biggest banks shrank in 2015, as the sector weathered a year of central bank rate cuts and saw an end to easy profits after the government lifted the cap on interest rates on deposits.
与2013-2014赛季的世界各大足球联赛相比,本届世界杯的场均进球确实更多。荷甲以场均进球3.2个高居欧洲各大联赛之首,德甲则以3.16个紧随其后。上个赛季,其他联赛的场均进球都没有超过2.8个。目前,美国职业足球大联盟的场均进球为2.89个。
When Finnish programmer Jerry Jalava had a motorcycle accident in 2008, he faced a double tragedy. First, he lost his finger, an obvious problem for anyone who types for a living. Second, he had to deal with a medical team who thought they were comedians—learning of his profession, one surgeon joked that Jalava should go out and buy a “USB finger drive.”
Whedon had always loved the seemingly separate ideas of sci-fi and westerns, and through The Killer Angels, he saw a way to combine them. "I wanted to play with that classic notion of the frontier," he said. "Not the people who made history, but the people history stepped on—the people for whom every act is the creation of civilization." And Whedon decided to set the frontier on a spaceship: a ship named Serenity.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

德国
College graduates earn more
The Harry Potter star Emma Watson hold fifth position in the list of ten most beautiful women of 2015. The English actress, model, and activist, Watson took the top spot on the AskMen “Top 99 Outstanding Women 2015″ list and at number 26 on the TIME 100 list of the world's most influential people.
谷歌2017搜索排名靠前的包括马特·劳尔和飓风厄玛。搜索巨头公布了它今年的年度搜索结果榜单,内容主要是在全球各类行业中谷歌搜索排名靠前的几位。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

他赢得了名动词奖,而其姐妹奖,最佳动词名词化奖,则由另一位顾问凭借这句“全球联络”(global touch-base)摘得。
n. 银河,一群显赫之人

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

其它
Stand: Yahoo CEO Marissa Mayer defended work-from-home ban
'The market for colored diamonds is really, really high, because they are so rare,' he said.
INDOORS: This house was completed around 1848 and last updated in 2008. The front door has a transom and sidelights of red glass etched with a leaf motif. The first floor has a large living room with crown molding and two fireplaces, one of which warms the formal dining area. Off the living room is a family room with raised wall paneling, a wet bar and another dining area. French doors open to a slate patio. Several rooms have views of Little Narragansett Bay.
5.X-Men: Apocalypse

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Her device uses carbon nanotubes to detect the presence of lead. Thousands of US water systems are reportedly contaminated by lead.
I loved his list (hat tip to him), but I thought I’d elaborate on what I believe makes for an effective boss or manager。
If there are nine or 10 best picture nominees, it could grab a spot. Jordan Peele's screenplay looks certain to be recognized.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

Total migrant worker earnings are estimated to be $3 trillion annually, of which approximately 85 percent remains in the host countries. The money migrants send home averages less than one percent of their host country's gross domestic product, IFAD said.
10. 注意自己的心态。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

在韩国首都首尔,20%年龄介于19到49岁的女性承认她们为了改变样貌,接受过美容整形手术。
(G.I. Joe: Retaliation)以及两部小规模电影,加起来在全球的票房收入总计13亿美元。
该项目在毕业3年后的职业晋升方面排名第二。Tiemba项目的毕业生数量迄今只有约250人,使他们成为一个精英团体。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

STEP 7: DEVELOP a special interest
Remedy: While the idea of being your own boss is an attractive one, not everyone is cut out to be an entrepreneur. Being responsible for your own success, creating a legacy for your family and improving the lives of clients and customers certainly sounds romantic, but what about the long hours, the lack of leisure time, the risk of financial failure, the fact that you’re the boss, entry-level employee, marketer, accountant and janitor all rolled into one? If you value job stability, prefer a singular focus over multi-tasking, aren’t particularly comfortable with risk and can’t imagine yourself hustling for new business on a daily basis, the entrepreneurial lifestyle isn’t for you.
adj. 不可否认的,无可辩驳的

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

v. 引诱,吸引

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
From the themed collection: 成都家居商圈 掀起体量之战
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

艾丽斯·斯瓦策尔(Alice Schwarzer)

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Manal al-Sharif
5. Caterpillar

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Property prices in Hong Kong have surged over the past decade, but hit a peak in September when jitters about China’s economy took hold.
An early iteration of Summly, called Trimit, was featured in Apple's app store in July 2011 on a list of new and noteworthy offerings. There it was noticed by the influential Silicon Valley blog TechCrunch and quickly came to the attention of an investment group led by Li Ka-shing. When D'Aloisio was approached over email by Li's people at Horizons Ventures, he was only 15-and so far mostly managed to conceal that fact. He'd never met with anyone in the tech world face to face, and the information he'd listed when he registered Trimit spoke only vaguely of a London technology company. It failed to mention that the company's management and technology teams-in fact, its entire workforce-consisted of a single kid in a suburban bedroom who wasn't yet old enough to drive.
Although foreign trade accounts for a greater share of the economy than ever, the United States is still more insulated than virtually every major competitor in Europe and Asia. Such everyday purchases as haircuts, dry cleaning, financial advice and eating out are virtually immune from foreign competition.
居民消费价格上涨2%;

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

受到好的affect影响就充满爱affection,受到不好的影响affect就学会假装affected
"They are fairies. Can’t they do something else except falling in love?" another Douban user Amy said.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

这是自从2001年来第一次由一名既不是小梅瑟威、也不是泰格·伍兹的运动员,荣登收入榜第一名。
你可能从未想过一根皮带可以与人工智能相结合,但Belty做到了,并使它看起来很时尚。这个belty会让你不自觉就觉得,“为什么我需要这个?”然后你想可能会是,“如果是黑客入侵,他们把它系得很紧我不能呼吸该怎么办?”第一个问题是合理的;第二个问题有些牵强,但如果它让你三思而后买这个产品,这并不是一件坏事。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

那些具有3年驾驶经历,无重大交通事故、危险驾驶、吸毒、酒驾记录的司机将可参加网约车考试。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

7. AT&T
6月28日
The average pay for executives in educational companies was the lowest, just over 2.8 million yuan and about one tenth that of their counterparts in the financial sector.
天文学家在2016年宣布,LIGO阵列检测到了两个黑洞碰撞所释放出来的引力波,证实了爱因斯坦广义相对论的关键部分。研究人员因这项发现而获得了诺贝尔物理学奖。但是研究人员的发现仍未结束:10月,科学家们监测到了两颗中子星的碰撞,不仅听到了碰撞造成的时空涟漪,而且还用性能强大的望远镜在光学上确认了这一事件。中子星的碰撞被认为是宇宙中所有重金属的来源,包括黄金和白银,LIGO的探测有助于验证有关宇宙化学形成的解释。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
From the themed collection: 住进“甲醛房” 老租客心里慌
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

['depjuti]
另一个出人意料的新领域是纳米技术。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

中国国产3D奇幻/冒险片《捉妖记》2015年7月在国内上映后打破一系列票房纪录,成为2015年中国内地最卖座的电影
5、Poor e-mail communication
两岸是骨肉同胞,血浓于水,不管岛内形势如何变化,都割断不了两岸的亲情,也改变不了我们维护两岸关系和平发展的决心和诚意。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

adj. 终极的,根本
新美国基金会(New America Foundation)高级研究员李?德鲁特曼(Lee Drutman)在一份给Vox的分析文章中指出,在阿肯色州、北卡罗莱纳州和田纳西州,移民人口是1990年的三倍以上。围绕这些变化产生的焦虑或许可以解释共和党为什么在这个阶段更关注限制移民问题,还有这些州的白人投票者们何以压倒性地支持特朗普。
To Rouslan Krechetnikov and Hans Mayer for studying the dynamics of liquid-sloshing, to learn what happens when a person walks while carrying a cup of coffee. I'll give you a hint: it happens between step 7 and 10.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Bursts of color are instant energy suppliers. If you can, paint your walls or use furniture and accessories to provide a colorful oomph.
在过去的12个月里,这位22岁的T台女王兼真人秀明星赚得2200万美元,首次登顶福布斯模特收入榜。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

这封情书是寄给一个叫做Clark C Moore,但是现在已经改名为Muhammad Siddeeq先生的,由于这次改名,让这封信找到真正的收件人变得尤为困难。
Last year, the Education Ministry issued a booklet warning Korean high school students of 'plastic surgery syndrome', citing Michael Jackson and a local woman whose addiction to plastic surgery left her with a grotesquely swollen face.
Led by Letv, Anbang and Eastmoney, 26 newcomers are on the list; 70 percent are privately held. Mi was the fastest riser, with its value shooting up fivefold year-on-year, to come in at $7.3 billion, followed by TCL and Huawei.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Frankly, this is unlikely to be ready in time for next year, but we'll include it just in case. The second film from Laszlo Nemes, who won the foreign language Oscar earlier this year for Son of Saul, is a coming-of-age drama set in Budapest just before the first world war.
在定制课程排行榜上,排在第二名瑞士洛桑国际管理发展学院之后的是杜克企业教育学院(Duke Corporate Education)。这是这所美国学校连续第3年位列第三。该校在2014年连续第12年占据定制课程排行榜榜首位置,创下纪录。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 房地产税法总体思路正在坐实
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

郭晶晶与霍启刚(香港近代富豪霍英东的孙子)的秘密恋情已经引起了全民的想象,人们似乎在关注运动员赛场表现之余,也愈加关心起他们的私人生活了。
11月,由财新网(Caixin)赞助的中国制造业采购经理人指数(PMI)初值为48.6,高于预期的48.3。而10月份该读数则为48.3。读数显示上个月中国制造业活动在继续放缓,不过情况没有10月份那么糟糕。
中国一群现代汽车经销商要求韩国现代汽车赔偿8-9亿元(1.2-1.35亿美元),称现代汽车削减了向他们出口的车型,导致经销商亏损严重。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

When I find myself wanting to shout “No!” to an opportunity, that’s a sure sign to me that the answer should probably be “Yes.” So, I take a deep breath and analyze the situation as objectively as possible.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 中介大战 年底再度迎来升级
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

日前,斯坦福大学商学院(Stanford Graduate School of Business)教授彼得o库迪斯基于这场荷兰危机共同撰写了一篇文章,围绕“个人经验(而非市场信息)决定乐观、悲观以及信贷的获得与否”这种不那么科学的方法给出了现代经验。
会。梅亚德是执政党革命制度党(PRI)的候选人。他主要的竞争对手是强硬的左翼领导人安德烈斯曼努埃尔洛佩斯奥夫拉多尔(Andrés Manuel López Obrador)——可以感召人群的激情演说家。梅亚德需要克服很多问题:在去年1月一夜间把油价上调20%、引发通胀飙升后,他必须说服选民自己仍然是可以信任的。他还必须证明自己是个有主见的人,而不仅仅是这届不受欢迎的政府的傀儡——在遏制猖獗的腐败和犯罪行为方面,这届政府极为失败。但是凭借强大的PRI拉票机器,他可能势不可挡。在墨西哥只有一轮选举的体制下,30%的选票可能就足以让他当选总统了。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

If Dwyane Wade lost 30 pounds of muscle, you wouldn't be able to tell him apart from the high school version of himself.
Born to royalty in Burma, Olive Yang, who died on July 31, rejected her birthright to become a cross-dressing warlord and opium trafficker.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 2015财年涂料巨头净利润大幅增长
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

中国在朝鲜半岛问题上的立场是明确的、一贯的,坚持实现半岛无核化,坚持维护半岛的和平稳定,坚持通过对话协商解决问题。
Accelerating price growth for new housing in cities across China lost more steam in November amid a flurry of purchasing curbs in major cities, though price gains from a year earlier remained comfortably in double-digit territory.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

capacity
“这可是短期内的大幅跃升:当我还是内政部长时仅有30个案例,今天则是1400。”

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

然而我知道,你们这一代人不同于过去的任何一代人,极其渴望体会不同以往的人生。所以,在你们离开学校之际,我要向你们介绍几条显而易见、却容易忽略的真理,帮助你们以略微不同的角度来看待生活,而不是仅凭一叠薪金来认识世界:

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

他说:“国内需求增长太慢,而新增出口订单的增幅又放缓至5个月内的低点……我们依然预计(中国政府)会推出进一步货币和财政宽松举措,以抵消经济增长的下行风险。”
学员平均年龄:36岁
卷铺走人的时候
The names of some of these public Facebook groups, Mic reported, were "Harvard Memes for Elitist 1% Tweens", "UCLA Memes for Sick AF Tweens" and "USC Memes for Spoiled Pre-Teens".

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

你可能觉得我们对于列清单的爱好是从“十诫”继承而来,但安伯托·艾柯( Umberto Eco)的说法却正相反,“清单是文化的起源”,他写过一本书,《无限的清单》(The Infinity of Lists),书中在讨论自己熟悉的东西时这样说道。而且,文化希望“让无限变得可以理解”,并且“创造秩序——不是永远如此,但通常都是这样”,所以才有了荷马在《伊利亚特》中的人名清单,以及你冰箱上贴着的,永远做不完的家务清单。“我们喜欢清单,因为我们不想死,”艾柯还说,这可能是对“清单体”(listicle)的最佳解释了。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: “慢就业”能否“慢”出意义?
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

问:对于你的作品在西方广受欢迎一事,你是怎么看的?
Henda Ayari created a storm when she denounced radical Islam. Now, inspired by the #MeToo campaign, she has accused an Oxford professor of rape.
['mu:vm?nt]

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

我们要求FlightAware对航班抵达延误情况进行统计,而不是航班出发延误情况,因为有时候,航空公司可以让飞机在空中飞行期间追回地面上失去的时间。
2010年,马丁飞行器公司推出的喷气背包号称"世界上第一个盗版喷气背包"。这个喷气背包甚至还被列入《时代周刊》"2010年度50强发明"之一,因为众所周知世界上第一个喷气背包是在1958年发明的,且自1981年来一直在发展。喷气背包由温德尔·穆尔设计,他是贝尔空间系统公司的研究员。温德尔设计的喷气背包的早期模型飞行高度可达5米(16英尺),飞行时间为3分钟。这一点引起了美国军队的注意,美国军队便为这一项目投资了15万美元。后来,还特地为美国军队做了些试飞飞行器,也为肯尼迪总统做了飞行器。之后,因为飞行时间和飞行距离有限,美国军队取消了对这个项目后续研究的投资。美国航天局也想用喷气背包为阿波罗11号任务做支援,以防登机舱出故障。但之后还是改变了想法,改用了月球车。贝尔经历了这个挫折后,停止了对飞行器的进一步研究。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 陶瓷原料涨价的原因分析
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

Neshama Spielman, from Jerusalem, found the artifact four years ago at a dig organized by the City of David and the Temple Mount Sifting Project, which works to examine tons of dirt removed without archaeological supervision from the Temple Mount by the Muslim Waqf. Details of the find and its identification, however, have only now been revealed. Spielman, who is aged 12, was just 8 when she made the find.
这封情书是寄给一个叫做Clark C Moore,但是现在已经改名为Muhammad Siddeeq先生的,由于这次改名,让这封信找到真正的收件人变得尤为困难。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

经济学家的预期中值为同比上涨0.9%。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

The average monthly salaries for grads in law, engineering and medical majors are 5,545, 4,512 and 4,500 yuan respectively, slightly down from last year, while graduates with educational and agricultural majors are offered lower pay, at 3,258 and 3,184 yuan respectively.
discourse
The average pay for executives in educational companies was the lowest, just over 2.8 million yuan and about one tenth that of their counterparts in the financial sector.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

单词determine 联想记忆:
其中一本被标上"M3"的坟墓里包含有神兽的雕刻,其中有四只代表一年四季以及天堂的各个部分:西边的白虎,南边的朱红鸟,北边的黑龟,东边的青龙。
节目31 京剧《迎来春色换人间》,于魁智 托马斯(孔子学院学员)
该剧在今年暑期播出,受众的是喜欢奇幻浪漫题材的年轻观众。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

所估计的收入来自电影、电视、化妆品及其他公司代言。宝莱坞女星迪皮卡?帕度柯妮是唯一一位首次入围的女星。
10.Be Dedicated and balanced

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

创业者之间竞争的本质在于效率。好消息是,如今市面上已经有了好几千种优秀的应用软件,能令我们的生活变得更加轻松,但是你不可能有足够的时间把这几千种应用都试上一遍。那么,哪些应用值得你花时间试用一下呢?
译文属可可英语原创,未经允许,不得转载。
Weaker demand from emerging markets made 2015 the worst year for world trade since the aftermath of the global financial crisis, highlighting rising fears about the health of the global economy.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

The Amsterdam crisis began when a Dutch group known as the Seppenwolde syndicate made a big, contrarian bet on the shares of East India Company. Those shares had plunged in 1771 mainly because of losses in Bengal, but the company kept paying high dividends and covered up its shortfalls by borrowing money. Convinced that East India shares would quickly rebound, the Seppenwolde group aggressively bought them on margin. But instead of rebounding, the shares fell even further after the company slashed its dividend.
尽管当下是一个全球性的经济环境,但仅有约20%的美国人会说第二门语言。Sixty Vocab的目标就是以其在线外语游戏改变这一现状。基于2000个单词相当于一门外语的六成精髓的假设,Sixty Vocab试图使学习必要词汇的过程变得有趣。这些在线游戏能教你在对话中最为常用的词汇,并辅以限制时间的规则——你在越短的时间内猜出单词,你就能越快地进入到下一个阶段。Sixty Vocab填补了你高中课程和昂贵外语学习项目之间的空白,为那些想要在早餐咖啡或通勤时间学习一门外语的人提供了一个独一无二的选择。

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